The University of Manchester -Molecular Cancer Research Group
Faculty of Life Sciences
Closing date: 06/01/2014
Reference: LSX-03748
Faculty / Organisational unit: Life Sciences
School / Directorate: Life Sciences
Employment type: Fixed Term
Duration: Until 26 January 2017
Location: Oxford Road, Manchester
Salary: £40,178 per annum
Hours per week: Full time
Reference: LSX-03748
Faculty / Organisational unit: Life Sciences
School / Directorate: Life Sciences
Employment type: Fixed Term
Duration: Until 26 January 2017
Location: Oxford Road, Manchester
Salary: £40,178 per annum
Hours per week: Full time
PloidyNet is a Marie Curie Initial Training Network (ITN) financed by the European Commission’s Seventh Framework Programme in the context of People-Marie Curie Actions. PloidyNet brings together 9 academic and 3 industrial partners throughout Europe, to train 11 promising scientists in the field of aneuploidy over the next four years.
Every cell division, the duplicated genetic material must be faithfully distributed to both daughter cells during the chromosome segregation process. When chromosome segregation is flawed, the emerging daughter cells acquire unbalanced chromosome content, a state known as aneuploidy, a hallmark of cancer cells. However, aneuploidy itself appears to have detrimental consequences for cells, inhibiting rather than stimulating cell proliferation. Because cancer cells proliferate despite aneuploidy, it appears that they acquire mutations that allow then to tolerate genetic imbalances. How this occurs at the molecular and cellular level, and thus how aneuploidy contributes to malignant transformation, remains unclear.
The scientific challenge of PloidyNet is thus to determine and compare the molecular consequences of different levels of aneuploidy. To accomplish this, PloidyNet brings together leading Europe labs including those of René Medema (Amsterdam), Floris Foijer (Groningen), Geert Kops (Utrecht), Stephen Taylor (Manchester), Bill Earnshaw (Edinburgh), Erich Nigg (Basel), Zuzana Storchova (Martinsried), Rocio Sotillo (Rome) and Charles Swanton (London). The network also includes three biotech partners, NTRC, Miltenyl and Syncom.
PloidyNet will train a total of 9 PhD students (early stage researchers) and 2 postdocs (experienced researchers) Students will benefit from the vast expertise of the participating labs, and thus be exposed to ground-breaking research, state of the art techniques plus several model organisms, in both academic and biotech environments.
All investigators and trainees will meet at a yearly conference to exchange and discuss results, thus fostering healthy, collaborative interactions with other labs and enabling the creation of a scientific network for the future. As such, PloidyNet students are likely to be future leaders in the field of aneuploidy.
One Early Stage Researcher is sought to join Professor Stephen Taylor’s lab at the University of Manchester with a view to dissecting a p38 stress response mechanism that limits the proliferative potential of aneuploid cells. The ESR will be expected to work towards a PhD through registration at The University of Manchester.
Please note there are strict eligibility requirements which apply to all Marie Curie Early Stage Researchers. At the time of appointment, you should not hold a PhD or have more than 4 years’ research experience (FTE) after Masters graduation (applicants may have spent longer in industrial/junior management roles) and you should not have resided in the UK for more than 12 months in the last 3 years immediately before appointment.
Informal enquiriesInformal enquiries can be made to Stephen Taylor
Email: stephen.taylor@manchester.ac.uk
Email: stephen.taylor@manchester.ac.uk
The University of Manchester values a diverse workforce and welcomes applications from all sections of the community.
Further particulars including job description and person specification are available on the University of Manchester website - click on the 'Apply' button below to find out more.
